I had previously tried it on two different tablets with the same result. One runs Android 2.3 and the other is on 3.1.
I just now tried it on the emulator and it did the same thing.
I just discovered that if I put a break point on an early line in Activity_Create, then Debug works. So I pressed F8 for a couple of dozen lines and when it got to a particular line (nothing special about it -- just like the lines above it) and pressed F8, the Debug line highlighter disappeared and the code started running like I had pressed F5. In a few seconds, the Debug window at the bottom of the screen closed. The app continued running.
I tried it again and the same thing happened. I tried deleting a line of code above it and instead of the problem happening on the same line of code as before, it happened on the next line.
Thinking that it might be a memory problem, I removed the code for several subs, ran it again, and the same thing happened.
I then stopped and restarted with some break points below the line where Debug was disappearing. I pressed F8 up to the same line and the Debug highlighter disappeared, but the tablet showed a box saying that the program was paused on the next break point and the Debug window did not disappear.
Now I could continue pressing F8 to single-step. The Debug highlighter did not show, but the box in the app kept showing the line it was on. I could not hover over a variable to get its value.
I pressed F5 and the app started running, but stopped on a break point 5000 lines down, but the lines in the code edit window did not change to show the break point.
So if I put a break point early in Activity_Create and single-step up to the point that Debugs quits, the Debug window will disappear, but if the first break point is after that line, Debug quits working, but the window does not disappear, even though it no longer is updated.