Don't use InitializeSQLite. Use Initialize or Initialize2. Something like
sql.Initialize("com.sqlite.JdbcUrl","jdbc:sqlite:test.db")
That should open an unencrypted test.db SQLite database file that is located in the same directory as the the program file (.jar) or, while developing, in the Objects directory of your project. Note: The test.db must exist, so you either need to use InitializeSQLite to create the database file or another external program. Once you open the unencrypted DB, you can encrypt it as per documentation. You then need to change the URL to include the encryption parameters so the driver can properly open your database.