I don't know what you want to achieve, exactly.
You can load more than one layout into Root; all views will be displayed.
If you want to see one layout at a time, when needed, use Root.RemoveAllViews and load a different layout.
An alternative can be to create a basic layout, which contains for example 3 maximized panels, anchored on all edges, load this layout in Root, then load a layout in each of the 3 panels and use the BringToFront method of the panel you want to see; or set the visibility of the panel to be displayed to True and to False the other two.