Thanks for the tips, Erel.
One of the advantages of running on a virtual machine is that ability to snapshot. Luckily I did this before upgrading. I restored the snapshot, made a new directory and installed version 5.81 into that. Running the new version had the same results. I then re-ran it from the command like with the "-log" switch on. I killed the process after a while and saved the log (attached).
The problem seems to be a NullReferenceException, viz:
System.NullReferenceException: Object reference not set to an instance of an object.
at z.b(Int32 A_0, Object A_1)
The B4i v5.5 still works ok.
Any ideas?