In my case, the project I am currently working has almost 7000 lines of code, spread across 15 activities and involves 18 libraries as well. I normally use bridge to connect to my Nexus One to run this project. But when I make major changes to UI, I test it on my Galaxy Note too. So instead of switching bridge, I simply connect Note to my system via ADB over USB. And whenever I do this and hit F5 to compile, it takes over 90 seconds to finish "convert byte code" step. I also tried switching Nexus to ADB and Note to bridge but the result was same. As soon as I disconnect one of the devices from USB, the time drops to 25 seconds where it used to take 90 seconds. I have been seeing for the past 1 month during this development phase. May be it is due to my system but it sure happens.
And coming to my system it is an Athlon64 X2 3800+, with 3GB RAM, 2TB hard drive and GeForce 9600 GT graphic card, running Windows 7 Ultimate Edition 32 bit.