Bitmap.InitializeSample (which is similar to LoadBitmapSample keyword) loads the whole image. It down samples the image if it is larger than the specified dimensions.
For example, cameras usually produce huge images. In almost all cases there is no reason to load the whole image (which is much larger than the screen anyway). So when you use these methods the whole image is loaded by its resolution will be something like 200 x 200 instead of 4000 x 4000.