LOL.  $^@&ing technology.  It could be that you swapped from debug to release mode or vice-versa.  Or maybe B4A-Bridge lost and restarted connection.  Like, mostly when I F5, I get asked about scanning the app etc, but sometimes - no idea why - it skips that and just runs.  Still a mystery.  But as long as the app runs, I'm happy.
Back in 2018, sometimes B4A would go into a mode where it wouldn't run the app, ever after closing and restarting everything.  Only seemed to happen when a delivery deadline was approaching.  Nothing would fix it, and then a day or two later, it would start working again, all by itself.  Happened on different phones, too.  Also not just to me.  Anyway, whatever that $&#* was, seems to have been fixed.